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5% aqueous solution of so-called “sodium hexametaphosphate” (HMP) has been used clinically as a direct solubilizing agent of bile pigment calcium gallstones for more than 20 years. This solution has been found to he highly safe and to possess an excellent chelating action under a normal physiological condition. Since HMP is unstable in an aqueous solution, the preparation must be prepared just before clinical use. Further, it is very difficult to dissolve HMP in water and to adjust the pH of the solution.To overcome these difficulties, a new method for preparing HMP solution is used successfully. A commercially available HMP powder is dissolved in 7 % sodium bicarbonate solution to make 5% solution and filtered through a Milipore filter (pore size: 0.22-0.45μm) to eliminate bacteria and other contaminants. These procedures are simple and easy enough for dissolution and pH adjustment, and thus the solution may be prepared easily at any institutions just before infusion into patients with cholelithiasis.

New Method of Preparation of Hexametaphosphate Solution as Gallstone Solubilizer