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Injectable drugs are prepared on the premise of administration as a single item. However, in therapeutically needed cases, to reduce pain or for efficient practice, several injections are routinely mixed, especially with infusion solution or uid replacement, and then administered in a realistic medical setting. Mixed injections could, in theory, be more physically or chemically unstable than individual components. Thus, drug compatibilities associated with the coloration, precipitation or decrease of a titer, or increase of side effects may occur. Such drug compatibilities would not only be of great disadvantage for patients, such as the direct injection of unknown substances, but could also cause economic losses to medical institutions through waste of compatible injections. Therefore, it is very important to prevent drug compatibilities. Medical staff are required to understand the features of individual injectable drugs and their compatibilities. A manual on the operating procedure for the safe use of pharmaceutical preparations by the Research of Health, Welfare and Labor Sciences in 2006 includes a statement that indicates that the stability, incompatibility and compatibility of a drug should be confirmed, in the section related to the dispensing of injectable drugs, and that pharmacists should actively provide medical staff with information about such incompatibility, how to mix, the procedure for mixing, and procedures for administration in the section related to passing the prescription onto a

Compatibility of Heparin Sodium in Intravenous Line with Nicardipine Injected from a Side Tube via T-shape Stopcock