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Recently, the concept of “opioid rotation” has been proposed. The concept of “opioid rotation” is de ned as “treatment with the same opioid by an alternative route or with an alternative opioid administered by the same route when pain is relieved inadequately by opioid analgesics given in a dose that causes intolerable side effects despite routine measures to control them.” Other reasons for opioid rotation include inadequate analgesia even after increasing the dose or inability to give a drug orally . At the time of opioid rotation, changes in the type of opioid, dosage form, or route of administration necessitate dose adjustment to obtain a similar level of analgesic ef cacy. It is therefore necessary to establish dose equivalency among different opioid preparations, and dose-conversion ratios for various preparations have been reported . To our knowledge, however, no study has calculated dose-conversion ratios in patients undergoing opioid rotation from a continuous intravenous infusion of morphine hydrochloride (continuous in-

iryō yakugaku/iryou yakugaku

Dose Conversion during Opioid Rotation from Continuous Intravenous Infusion of Morphine Hydrochloride to Oral Administration of Oxycodone Sustained-release Tablets