English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In this study,we determined the optimal dose of levofloxacin (LVFX) in elderly patients with Streptococcus pneumoniae infection.For this purpose,we performed the Monte Carlo simulation to determine pharmacodynamic target attainment rates for several LVFX dosage regimens against Streptococcus pneumonia .In the simulation,we calculated area under the blood concentration-time curve (AUC)/minimum inhibitory concentration (MIC) values (n=98citation=6)and those over 25 were considered to be effective.The percentages of the LVFX MIC against Streptococcus pneumoniae (n=1citation=29)were 3%,56% and 36% at 0.5μg/mL,1μg/mL and 2μg/mL,respectively.In the elderly patients,the target attainment rate was 78.2% for those receiving a 250 mg once-daily dose of LVFX and 94.4% in those receiving a 500 mg once-daily dose.In a quarter of the patients surveyed,the creatinine clearance was less than 50 mL/min.Taking all of these findings into consideration,a 250 mg once-daily dose LVFX may be the optimal dose for efficacy.

Optimal Dose of Levofloxacin in Elderly Patients with Streptococcus Pneumoniae Infection Based on Monte Carlo Simulation