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隠 :諜 認 ゚7。,,。。,〕 Warfarin is thc only oral aniticoagulalit used in the preventi 〔m of thromboembollsm in ∫apa 冂 . Thc anticoagulant cffcct of warfarin is monitored by analysis of the prethrombLn complcx 〔lntemational Normalised Ratio, INR ), but in some cases , measurement of plasma warfarin concentrations is necessary . We developed simple and sensjtjve LC / 「 MS 〆MS methods for山is p し叩 ose ind 、validated it through assay of four warfari 且l monohydroxy 】atcd Inetabolites and warfa エin enantiomers in human p]asma , Preparatbn of san 〕ples from O,05 mL of p[asma involved simple protein precipitation using h}・drochlorjc acid 〆acetonitrile . Analytes remained stable during sample process − ing and storage . Chromatographic separation was conducted using a chiral (CHIROBIOTIC V ) column and an achiral (Symmetry Shield RP 田 )colum11 , No significavlt interference from human plasma components was obscrvcd . Assay lincarity was demonstrated for all anialytes widl the LC,・MS , 「MS system over the calibration r細 ge 2 to 50011g 「 ∫ mL . The jlltra −day

Simultaneous Assay of Warfarin and Its Metabolites, and Assay of Warfarin Enantiomers in Human Plasma Using LC/MS/MS System