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ticosteroids decreased the risk of severe exacerbation and improved asthma control in patients with mild persistent asthma, the IMPACT (Improving Asthma Control) study found that intermittent treatment with inhaled steroids had about the same rates of severe exacerbation and asthma-related lung function decline as those on the recommended standard daily controller medication. To determine whether these findings were valid and representative, we critically appraised the START study and the IMPACT study according to CONSORT. The START study was generally of high methodological quality but the IMPACT study had some weaknesses in study design, clinically relevant outcomes, and participant flow. Accordingly, most

A Critical Appraisal of the Literature on Inhaled Corticosteroid Therapy for Mild Persistent Asthma