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〔 Received June 6, 2003 Accepted December 29, 2003 〕 In the present study, the authors examined the change in thiamine content of a TPN fluid under clinical conditions, obtained Integrated Dose in Period (IDP) values and compared this data with IDP values calculated on the basis of stability data in the literature. We also determined the bisulfite ion concentration that affected the stability of thiamine in the TPN fluid. Our results showed that, 62.5 % and 59.5 % of the thiamine in the TPN fluid remained 24 hours after its preparation under light and dark conditions, respectively. The bisulfite ion concentration decreased from 0.279 mg/mL to 0.177 mg/mL under light and from 0.284 mg/mL to 0.227 mg/mL under dark conditions. While the IDP values that we obtained were less than those calculated on the basis of the literature, they were still over the daily thiamine requirement (1.3 mg), even after 48 hours. In conclusion, the authors demonstrated that the thiamine content of a TPN fluid could be maintained at an adequate level following preparation under the conditions of the daily clinical setting, and that one can rely on stability data from the literature for the purpose of estimating IDPs for vitamins.

Effect of Light and Sodium Bisulfite on the Stability of Thiamine in TPN Fluids and Integrated Dose in Period Values