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stoppers. The research was carried out by sticking a needle into a rubber stopper 30 times , and observing the core in the vial and also observing the interior of the stopper . As a result, the rubber stopper with the least amount of coring was the newly developed S 2-210N1. However, depending upon the needle used , coring occurred and protrusions and cracks in the rubber were confirmed in the interior of the rubber stopper . The best injection needle was found to be the PenNeedle 31G (PN 31 G needle) . However, coring occurred when used with the rubber stoppers PenFill R 300U and HumaCart R300 , which are currently sold on the market. The least amount of coring occurred with the combination of the S 2-210N1 and the PN31G . In addition, while an extreme amount of coring occurred with a MicroFine Plus 31G (BD31G needle) cut needle tip , little coring occurred with the non-cut needle tip, and it was discovered that the make-up of the needle tip of the injector is

The Occurrence of Coring in Multiple Combinations of Injection Needles for Insulin Self-injections and Rubber Stoppers