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PURPOSE: The development of cancer cachexia is the most common manifestation of advanced malignant disease. METHOD: The effects on muscle regeneration of β2adrenoceptor agonist formoterol (0.3 mg/kg) were tested in cachectic tumourbearing rats (Yoshida AH130 ascit es hepatoma). RESULTS: Administration of formoterol results in a significant increase in the mass and protein content of tibialis muscle in tumourbearin grats. This increase is associated with a decreased myogenin mRNA content together with an increased Pax7 gene expression. Bupivacaine treatment by local injection results in an important reduction in tibialis weight together with significant increases in Pax7, myogenin and MyoD gene expression. Formoterol treatment in bupivacainetreated rats results in significant increases in Pax7 together with significant decreases in myogenin mRNA content, suggesting that this β2agonist is favouring muscle regeneration by stimulating the proliferation of satellite cells. Altogether, the data reinforce the potential role of formoterol in the treatment of muscle wasting diseases.

Formoterol May Activate Rat Muscle Regeneration During Cancer Cachexia