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A 42-year-old man was admitted due to advanced nasopharynx cancer and administered a total dose of 19250 mg 5-fluorouracil (5-FU). On the fifth day, he exhibited acute consciousness disturbance, and the 5-FU administration was immediately stopped. An MRI revealed a high intensity lesion on the T2weighed image. The brain disease improved gradually. We do not have an effective cure for this disease but it must be detected early.

A Case of Leukoencephalopathy after Drip Infusion of 5-Fluorouracil (5-FU)