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Drug-ototoxicity due to transtympanic infusion of electrolyzed strong acid solution (ESAS) was studied electrophysiologically by auditory brainstem response (ABR) and morphologically by scanning electron microscopy (SEM) of inner ear. After undergoing pre-treatment ABRs in response to tone pips at 8 kHz and 16 kHz, eight guinea pigs were divided into the following two groups : group A (5 animals, in which ESAS was applied into tympanic cavities bilaterally once a day for five successive days) and group B (3 animals, in which instead of ESAS, physiological saline solution (PSS) was applied under the same conditions as a normal control). Post-treatment ABRs were measured 24 hours after the transtympanic infusion of ESAS or PSS, and all animals were sacrificed and the inner ears were removed for the examination of SEM. The results showed that there was no obvious morphological change of the sensory hairs in the organ of Corti, the macula and the ampulla following the transtympanic application of ESAS. Although among the group A, there was a slight elevation of ABR thresholds to be seen in 4 animals after the administration of ESAS, presumably it seems to be caused by the transitorily non-specific lesion of the tympanic membrane but not inner ear. Our findings suggest that ESAS might be considered as a useful and low-ototoxic disinfectant for the otologic treatment.

Experimental Study of the Ototoxicity of Electrolyzed Strong Acid Solution in Guinea Pigs