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Tympanic membrane perforation, among otic diseases, is an important condition often encountered in the routine outpatient clinic. There are many reports on experimental pathological study of animals trying to elucidate the healing process of tympanic membrane perforation. However, much remains to be clarified about the healing process and the various influencing factors. In recent years, studies are reported using growth factors for tympanic membrane perforation. Some growth factors accelerate the healing of tympanic membrane perforation. Studies using growth factors have great potential for elucidating the healing process.

Healing Process of Tympanic Membrane Perforation and Growth Factors