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We experienced a case of leukemic change of malignant lymphoma difficult to distinguish from acute lymphocytic leukemia. However, it was diagnosed as malignant lymphoma or leukemia from immature B-cell origin by retrospective immunohistochemical examinations (MT-1, MB-1, LCA, M1) along with investigations of cell surface markers. Immunohistochemical tests made it possible to differentiate T or B-cell classification, retrospectively. It is important to reduce the numbers of examination of cell surface markers and to select an effective combination.

Leukemic Change of Malignant Lymphoma or Leukemia? An Immunohistochemical Analysis