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We clinically studied the effectiveness of nasal nebulizer therapy with cefmenoxime hydrochloride (CMX) and nasal drops of povidone iodine for acute rhinosinusitis in children. We evaluated the results using the standard for new antibiotics of the Japanese Society of Chemotherapy. The subjects were 50 children with acute rhinosinusitis. By the standard for total evaluation, consisting of clinical and bacteriological study, the cure rate of the CMX nebulizer group was 68%, that of the group using nasal drops of povidone iodine was 23.1%, and that of the controls was 38.5%. The cure rate with nasal drops of povidone iodine was not higher than that with CMX nebulizer therapy. However, with the nasal drops of povidone iodine, in 2 of 3 cases, PISP (penicillin intermediately resistant S. pneumoniae) disappeared and in 2 of 2 cases, MRSA (methicillin-resistant S. aureus) disappeared. The nasal drops of povidone iodine were found to be effective for drug-resistant organisms such as PISP and MRSA.

The Effectiveness of Nasal Nebulizer Therapy with Cefmenoxime Hydrochloride and Nasal Drops of Povidone Iodine for Acute Rhinosinusitis in Children