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This study was carried out to determine the clinical effects of low-dose clarithromycin (CAM) therapy for the treatment of chronic tonsillitis. Forty-two patients were assigned randomly to two groups : 200 mg of CAM per day (test group) and 400 mg per day (control group) for 4 to 8 weeks. The final overall effectiveness rates inclusive of excellent or good efficacy were 64% for the test group, and 55% for the control group, respectively. No statistical differences were noted in terms of subjective or objective efficacy between two groups. No side effects were observed in the control group, whereas mild upset stomach appeared in one case in the test group. Low-dose application of CAM was thus proved to be as effective as standard application.It was speculated that the efficacy of low-dose CAM therapy is mainly attributable to the immunomodulatory effects of 14-membered macrolides. These results suggested that low-dose administration of CAM can be useful for the treatment of chronic tonsillitis.

Clinical Effects of Low-dose Clarithromycin (CAM) Therapy for Chronic Tonsillitis.