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Sixteen children with severe chronic sinusitis were treated with the low-dose long-term clarithromycin (CAM) administration. Patients showed marked improvement in the following symptoms; 66.7% for mucosal swelling, 60.0% for volume of rhinorrhea, 60.0% for quality of rhinorrhea and 73.3% for postnasal drip.Bacterial examinations were also performed before and after treatment. The incidence of H. influenzae was lower during the CAM therapy than erythromycin (EM) therapy, but the ratio of CAMresistant bacteria increased after treatment.

Clarithromycin(CAM) Treatment for Chronic Sinusitis and Change in the Bacterial Flora.