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The therapeutic effect of fludiazepam was studied in 72 patients with tinnitus. Subjects were given oral fludiazepam 0.75mg daily, and the severity of tinnitus was recorded before and two or four weeks after the start of administration.The medication was effective in 65.3% of the patients. The efficacy was 79.3% among 29 patients with tinnitus that disappeared after intravenous lidocaine injection, and 72.2% among 54 patients with tinnitus reduced to less than half by such injection. There was a significant difference between the efficacy in the patients with tinnitus reduced to less than half by the injection and that in other patients (p>0.05). However, the efficacy of fludiazepam did not correlate with findings of a psychological test (TMI test: Toho-medical index test).A side effect, sleepiness was detected in 15.3% of 72 patients. However, the side effect was not severe enough to require discontinuation of the trial.These results indicate that fludiazepam is useful in the treatment of patients with tinnitus, especially, that which can be reduced by intravenous lidocaine injection.

Clinical Effect of Fludiazepam on Tinnitus. Comparison with the Result of Lidocaine Test.