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The pressure difference between the perilymph and the endolymph following infusion of artificial endolymph into the endolymphatic space was studied in guinea pigs. The perilymphatic and the endolymphatic pressures were measured simultaneously with two sets of a servo-pulling system. Endolymphatic infusion caused pressure increases in both the endolymphatic and the perilymphatic spaces, but no significant pressure difference between them. Soon after the endolymphatic infusion, both pressures returned to nearly the initial levels. We conclude that the endolymphatic and the perilymphatic pressures are very closely related and there may not be a significant pressure difference between them in endolymphatic hydrops.

Pressure relationship between perilymph and endolymph after the infusion of artificial endolymph into scala media.