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Clinically, it is considered that application of a poultice, one of the major skills of nursing, is useful for reducing pain or edema of the skin. However, there is little scientific basis for the effects of a poultice on skin lesions. Therefore, this study focused on the effects of poultice application on lesions produced by extravasation of medical drugs. The lesions were produced on the backs of rats that had been administered a medical drug (Cercine(R))subcutaneously. After extravasation of the drug, a hot or cold compress was applied to the affected part of the skin for 30min. The hot poultice was hot, moist cotton maintained at a temperature of 41•}1•Ž for 30min. The cold poultice was cold, moist cotton maintained at a temperature of 21•}1•Ž for 30min. Both gross and microscopic examinations were performed. Biopsy samples were taken at 4 and 8hrs after extravasation of the drug for microscopic examination. The study showed that there were no macroscopic changes on the skin after application of either the hot or the cold poultice. However, microscopic examination indicated that cooling reduced the extent of subcutaneous edema and infiltration of inflammatory cells into the dermis, whereas with heating the inflammatory changes became progressively worse. These findings clearly demonstrate the effectiveness of cooling for lesions induced by extravasation of medical drugs.

Experimental Study of the Effects of Applying a Poultice to Skin Lesions Produced by Extravasation of Medical Drugs