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Purpose: We investigated whether matrix metalloprotease-9 (MMP-9) and bone morphogenetic protein-6 (BMP-6) of biopolymers can be used to assess pressure ulcers. We examined whether the quantity of both proteins in the ulcer exudate was associated with the DESIGN-R scores for the pressure ulcers. Methods: The concentrations of MMP-9 and BMP-6 in the exudate from pressure ulcers were measured. DESIGN-R scores were determined for the pressure ulcers. The associations between the biological markers (MMP-9 and BMP-6) and the DESIGN-R scores were calculated. Based on the DESIGN-R scores, the differences in the concentration of both proteins measured were also evaluated. Results: The concentration of MMP-9 was greater in the exudates from pressure ulcers with higher scores for D (depth), E (exudate), and G (granulation tissue) in the wound bed. BMP-6 in the pressure ulcer exudate correlated with higher scores for P (pocket, undermining formation) in the wound edge. Furthermore, it was suggested that by estimating concentrations of MMP-9 and BMP-6, a judgment of severity was possible individually based on the exudate from the depth (D) of the wound bed and pocket (P) of the wound edge. Conclusion: The amounts of MMP-9 and BMP-6 in the wound exudates could be utilized as biological markers for the assessment of pressure ulcers.

A Basic Study of Assessment Tool Development for Pressure Ulcer: Possibility That a Biopolymer Marker can be Used