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Recently, we reported that astrocytes in the trigeminal caudal nucleus (Vc) of the brain stem express a purinergic receptor P2X 3 , which is involved in the craniofacial pathologic pain. Although we observed protein expression of P2X 3 receptors (P2X 3 Rs) in the astrocyte of the Vc, it is still unclear that astrocyte has functional P2X 3 Rs in Vc. To address this issue, we recorded asrtocytic P2X 3 Rs by using whole cell voltage-clamp recording in the Vc of the GFAP-GFP mice, which was used as a guide to astrocytes with green fluorescence. While measuring voltage ramp-induced astrocytic membrane current, we found the amplitude of the current was increased when we applied P2-purinoreceptor agonist, α,β-meATP. This increase was blocked by co-application of A317491, P2X 3 R antagonist. These results demonstrate that astrocytes in the Vc express functional P2X 3 Rs, which might be critical in craniofacial pathologic pain.

Electrophysiological Evidence for Functional Astrocytic P2X3 Receptors in the Mouse Trigeminal Caudal Nucleus

Electrophysiological Evidence for Functional Astrocytic P2X₃ Receptors in the Mouse Trigeminal Caudal Nucleus