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©2013 Turkish League Against Rheumatism. All rights reserved. Randomized placebo-controlled trials are considered to be essential because they are expected to provide unbiased results. However, numerous problems have been reported to be associated with systematic biases.[1] Among these biases, the attrition bias is somewhat different in that it cannot be controlled solely by the effort of researchers. This type of bias was emphasized by a previous study finding in which many participants with knee osteoarthritis (OA) dropped out of the trials due to complaints of ineffectiveness and adverse events.[2] Because attrition bias is inherently related to the participants themselves, researchers have developed indirect methods whereby it can be prevented.

Caution Should Be Observed Against the Last Observation Carried Forward Analysis in Opioid Trials