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There are a number of promising candidates for biomarkers such as urinary C-terminal telopeptide of type II collagen and serum cartilage oligomeric matrix protein, while none is sufficiently discriminating for diagnosis or prediction of prognosis in patients or for use as a surrogate outcome in clinical trials.[4] However, the combination of specific markers seems to improve the prediction of disease progression at the individual level.[5]

The role of biomarkers in osteoarthritis and osteoporosis for early diagnosis and monitoring prognosis