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Although MPV can be easily obtained with automated blood counters, the measurement of this parameter still has no standardization.2 Jackson and Carter3 had reviewed the variables affecting the values of MPV including time of analysis after venepuncture. Ethylenediaminetetraacetic acid, the most commonly used anticoagulant, causes time dependent platelet shape changes. Maximal variation occurs within the first two hours after venepuncture. Generally, the MPV multiplies up to 30% within five minutes of exposure to ethylenediaminetetraacetic acid and increases additionally 10-15% over the subsequent two hours.3 On the other hand, the MPV values vary being instrument-specific. With a meta-analysis, Beyan and Beyan4 showed that the measurement times between 15 minutes and two hours were significantly different from the measurement times shorter than 15 minutes and longer than two hours. Also, they found that the MPV values measured with Sysmex (Sysmex Corporation, Kobe, Japan) were significantly higher than the MPV values measured with Beckman Coulter (Beckman Coulter Inc., Fullerton, California, USA), Abbott CELL-DYN (Abbott Laboratories, Abbott Park Road, Illinois, USA), and Siemens ADVIA (Siemens Healthcare GmbH, Erlangen, Germany). The MPV measurements varied up to 17.8% by the instruments and maximum deviation together with the difference of instruments used plus MPV measurement times was up to 27.7%.4 Preanalytic variabilities like measurement time cannot be ignored becau se these factors affect the results considerably. Therefore, the MPV studies should be performed prospectively. The data of the study of Ayna et al.1 were obtained retrospectively from the files of the patients between January 2000 and June 2015. Because the measurement times after venepuncture and used instruments for blood counting were not known in this study, the data reliability was questionable. Actually, it is widely accepted that MPV has presently no role in establishing diagnosis and defining prognosis in any acquired illness.2

Mean Platelet Volume Values May Have not a Predictive Role for the Presence of Nephritis in Systemic Lupus Erythematosus Patients