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Cyclophosphamide (CPH) is a widely used chemotherapeutic drug that can affect the hippocampal neurocytes with a subsequent effect on memory and cognitive functions. Nanomedicine has the potential to overcome the current chemotherapeutic side effects, because of the unique nanoscale size and distinctive bioeffects of nanomaterials. So, the present study aims to investigate the potential ameliorative effect of the biologically synthesized nano-selenium (nano-Se) on CPH induced hippocampal neurotoxicity.

folia morphologica

Ameliorating effect of selenium nanoparticles on cyclophosphamide-induced hippocampal neurotoxicity in male rats: light, electron microscopic and immunohistochemical study