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Early life adversity (ELA) is not uncommon in major depressive disorder (MDD) patients. Childhood trauma has been reported more frequently in adult MDD patients relative to healthy controls. Recent researches have demonstrated that ELA could result in changes in brain morphology which might be an aetiological factor of MDD development.

folia morphologica

Early life adversity induced third ventricular enlargement in young adult male patients suffered from major depressive disorder: a study of brain morphology