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The astrocytic S100b calcium-binding protein performs numerous intra- and extracellular functions, promoting the survival of central nervous system (CNS) structures. Its increased synthesis and release are a manifestation of reactive glial behavior, crucial for the maintenance of proper neuronal function, particularly under the pathological conditions. The periaqueductal gray matter (PAG) is a mindbrain area composed of four parts dorsomedial (dm), dorsolateral (dl), lateral (l) and ventrolateral (vl)) which are involved in pain sensing and defensive reactions of the body. The aim of this study was to evaluate the S100b protein immunoreactive (S100b-IR) astrocytes in adult rats after administration of monosodium glutamate (MSG).

Reactivity of astrocytes in the periaqueductal gray matter of rats treated with monosodium glutamate