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Pentraxin 3 (PTX3) is an acute phase protein that, likely to C-reactive protein (CRP), belongs to pentraxin superfamily. PTX3 is produced as a response to inflammatory mediators by several types of cells directly associated with atherosclerosis such as endothelial cells or macrophages. Thus PTX3 appears to be a specific indicator of localized inflammatory process. PTX3 reflects inflammatory status in cardiovascular diseases such as subclinical atherosclerosis, coronary artery disease, acute coronary syndromes (ACS) and heart failure. Association of PTX3 with cardiovascular risk factors suggests that it can be a promising marker of subclinical and symptomatic atherosclerosis. Previous research suggests that PTX3 may be a useful diagnostic marker of ACS. Furthermore, in patients after ACS or with heart failure it appears an independent prognostic factor.

Pentraksyna 3 jako niezależny marker rozwoju choroby wieńcowej, stopnia jej zaawansowania oraz rokowania