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The mechanism of in-stent restenosis (ISR) is multifactorial, which includes biological, mechanical and technical factors. This study hypothesized that increased inflammatory reaction, which is known to be an important atherosclerotic process, at a culprit lesion may lead to higher restenosis rates.

In-stent restenosis-prone coronary plaque composition: A retrospective virtual histology-intravascular ultrasound study