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Myxomas are the most common primary cardiac neoplasm. Usually, myxomas originate in the left atrium, and their implantation base is in the interatrial septum [1]. Large atrial myxomas can produce stenosis or mitral regurgitation. Generally, these mitral valve diseases tend to be reversible and disappear following the tumor resection [2], however, large myxomas with long-term evolution may permanently affect the mitral valve structure and may cause persisting damage of the valve after complete resection of the tumor [2–4]. At the same time, atrial myxomas may conceal or underestimate a preoperative mitral regurgitation, from any cause [1, 2, 5, 6].

Giant left atrial myxoma hiding severe preoperative mitral regurgitation