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References: 1. Grigorakos L, Sakagianni K, Tsigou E, Apostolakos G, Nikolopoulos G, Veldekis D: Outcome of acute heroin overdose requiring intensive care unit admission. J Opioid Manag 2010; 6: 227−231. 2. Ridgway ZA, Pountney AJ: Acute respiratory distress syndrome induced by oral methadone managed with non-invasive ventilation. Emerg Med J 2007; 24: 681. 3. Pichot C, Petitjeans F, Ghignone M, Quintin L: Swift recovery of severe acute hypoxemic respiratory failure under non-invasive ventilation. Anaesthesiol Intensive Ther 2015; 47: 138−142. doi: 10.5603/AIT.a2014.0053. 4. Nava S, Navalesi P, Gregoretti C: Interfaces and humidification for noninvasive mechanical ventilation. Respir Care 2009; 54: 71−84. 5. Storre JH, Bohm P, Dreher M, Windisch W: Clinical impact of leak compensation during non-invasive ventilation. Respir Med 2009; 103: 1477−1483. 6. De Keulenaer BL, De Backer A, Schepens DR, Daelemans R, Wilmer A, Malbrain ML: Abdominal compartment syndrome related to noninvasive ventilation. Intensive Care Med 2003; 29: 1177−1181. 7. Aggarwal NR, Brower RG: Targeting normoxemia in Acute Respiratory Distress Syndrome may cause worse short-term outcomes because of oxygen toxicity. Ann Am Thorac Soc 2014; 11: 1449−1453. doi: 10.1513/AnnalsATS.201407-297PS. 8. Antonelli M, Conti G, Moro ML et al.: Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study. Intensive Care Med 2001; 27: 1718−1728. 9. Antonelli M, Conti G, Esquinas A et al.: A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome. Crit Care Med 2007; 35: 18−25. 10. Blomström-Lundqvist C, Scheinman MM, Aliot EM et al.: American College of Cardiology; American Heart Association Task Force on Practice Guidelines; European Society of Cardiology Committee for Practice Guidelines. Writing Committee to Develop Guidelines for the Management of Patients with Supraventricular Arrhythmias. ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: a report of theAmerican College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients with Supraventricular Arrhythmias). Circulation 2003; 108: 1871−1909. 11. Dhokarh R, Li G, Schmickl CN et al.: Drug-associated acute lung injury: a population-based cohort study. Chest 2012; 142: 845−850.

Cut-off point for switching from non- -invasive ventilation to intubation in severe ARDS. Fifty shades of grey?