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The present issue of ADMET and DMPK is dedicated to the 6 IAPC Meeting which was organized as a joint event consisting of 6 World Conference on Physico-Chemical Methods in Drug Discovery and Development (PCMDDD-6) and 3 World Conference on ADMET and DMPK (ADMET-3). The meeting took place in Hotel Westin, Zagreb, Croatia, September 04-07, 2017. IAPC meetings are organized as annual events in alternating European and East Asia locations. The topics covered the broad range of methods used in successful drug candidate identification and development. Determination of ADME/Tox properties through the in vitro and in vivo assays was discussed. The particular attention was paid to the evaluation and improvement of critical drug parameters which determine the fate of the drug, from its administration over its remedial action to its excretion. Roughly, six sessions were organized: Drug Development, Solid State, Pharmaceutical Cocrystals, PhysChem and Permeability, ADMET and DMPK and Drug Discovery. Special evening session “Pharmaceutical Cocrystals – Physicochemical Properties and Formulations” was organized and moderated by Alex Avdeef. The session highlighted issues related to the measurement of physicochemical properties, particularly dissolution and solubility as a function of pH, in support of formulation development of oral drug products with improved bioavailability.

admet and dmpk

Special issue devoted to the 6th IAPC Meeting: joint events comprising 6th World conference on physico-chemical methods in drug discovery and development and 3rd World conference on ADMET and DMPK