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Rifampin (RMP) resistant Mycobacterium tuberculosis is usually assumed to be resistant to all rifamycins. Increasing evidence indicates, however, that some rpoB mutations, detectable by rapid molecular diagnostics, confer resistance to RMP but not to rifabutin (RBT), suggesting that RBT may be effective for the treatment of M. tuberculosis with these mutations.

the international journal of tuberculosis and lung disease/the international journal of tuberculosis and lung disease. articles traduits en français ...

Predicting differential rifamycin resistance in clinical &lt;I&gt;Mycobacterium tuberculosis&lt;/I&gt; isolates by specific &lt;I&gt;rpo&lt;/I&gt;B mutations