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Following the World Health Organization's endorsement of the Xpert® MTB/RIF assay, which rapidly and simultaneously diagnoses tuberculosis (TB) and detects resistance to rifampin (RMP), the question arises to what extent RMP resistance is an adequate marker for multidrug-resistant TB (MDR-TB). A retrospective analysis of data from &gt;81 countries and subnational settings demonstrated that &gt;40% of RMP-resistant isolates from new TB cases did not display resistance to isoniazid (INH) in settings with relatively low MDR-TB prevalence (one third of all countries and subnational settings). Results indicated the need for INH susceptibility testing in addition to RMP susceptibility testing.

the international journal of tuberculosis and lung disease/the international journal of tuberculosis and lung disease. articles traduits en français ...

Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis [Short communication]