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Using a silkworm evaluation system, we previously evaluated various substances that suppress postprandial hyperglycemia. Enterococcus faecalis YM0831, a lactic acid bacterium that inhibits glucose uptake by the human intestinal Caco-2 cell line, exhibited hyperglycemia-suppressing effects in the silkworm system. In the present study, we found that Kothala himbutu (Salacia reticulata) extract, a traditional medicine containing α-glucosidase inhibitors, suppressed sucrose-induced hyperglycemia in the silkworm system. Moreover, combined oral administration of lactic acid bacteria YM0831 with Kothala himbutu extract had stronger suppressive effects on sucrose-induced hyperglycemia than single administration of either component. These findings suggest that the silkworm system provides a simple way to evaluate the effects of supplements on the suppression of blood glucose level induced by sucrose ingestion.

drug discoveries and therapeutics

Additive effects of Kothala himbutu (&lt;i&gt;Salacia reticulata&lt;/i&gt;) extract and a lactic acid bacterium (&lt;i&gt;Enterococcus faecalis&lt;/i&gt; YM0831) for suppression of sucrose-induced hyperglycemia in an &lt;i&gt;in vivo &lt;/i&gt;silkworm evaluation system