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Objective: Aurora kinases, which are serine/threonine protein kinases, are important molecules responsible for proper mitotic progression of cells. It is known that Aurora kinases are abnormally expressed in cancer cells. Therefore, they are seen as an important therapeutic target. CCT137690 is a synthetic aurora kinase inhibitor with high selectivity. In this study, it was aimed to determine apoptotic and antiproliferative effects of CCT137690 on KU812 cells (human chronic myeloid leukemia-CML). Patients and Methods: The cytotoxic effect of CCT137690 in KU812 cells was determined by WST-8. Effect of IC50 dose on apoptosis and on cell cycle was assessed with flow cytometry after using Annexin V-FITC Apoptosis Detection Kit I and BD Cycletes Plus DNA Reagent Kit, for apotosis and cell cycle, respectively. Aycan AŞIK1, Çağla KAYABAŞI1, Besra ÖZMEN YELKEN1, Tuğçe BALCI OKCANOĞLU2, Sevil GONCA1, Fatma SÖĞÜTLÜ1, Röya GASIMLI1, Sunde YILMAZ SÜSLÜER1, Çığır BİRAY AVCI1, Cumhur GÜNDÜZ1 1 Ege Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İzmir, Türkiye 2 Yakın Doğu Üniversitesi Sağlık Hizmetleri Meslek Yüksekokulu, Lefkoşa, Kuzey Kıbrıs Türk Cumhuriyeti Araş. Gör. Aycan AŞIK Ege Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İzmir-Türkiye Geliş: 30.11.2017 Kabul: 14.12.2017 E-posta: aycan.ask@gmail.com Yazışma Adresi ARAŞTIRMA LLM Dergi 2017;1(4):92-96 • 10.5578/llm.66266

CCT137690, Inhibitor of Aurora Kinase, Can Stimulate Apoptosis in Chronic Myeloid Leukemia Cells