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hipertansiyonda kombinasyon tedavisiyle ilgili yapilan ca- lismalardan elde edilen veriler celiskilidir. Bazi calismalar- da bosentan tedavisine sildenafi l eklenmesi hemodinamik ozellikleri ve egzersiz kapasitesini artirirken; bazi calisma- larda kombinasyon tedavisi etkisiz bulunmustur(23). Fakat yine de dogumsal kalp hastaligiyla iliskili pulmoner arte- riyel hipertansiyon hastalarinin, pulmoner arteriyel hiper- tansiyon spesifi k tedaviden fayda gordugu gosterilmistir. Ortalama dort yil takip edilen toplam 229 Eisenmenger sendromlu hastada yapilan retrospektif bir calismada pul- moner arteriyel hipertansiyon spesifi k tedavi goren grupta, tedavi almayan gruba gore daha dusuk olum orani saptan- mistir(24)

koşuyolu heart journal

Treatment Strategies of Pulmonary Arterial Hypertension Associated with Congenital Heart Defects with Shunt: A Group of Important Intensive Care Patient in Cardiology and Cardiovascular Surgery