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method for treating mandibular prognathism, distraction osteogenesis (DO) of the maxillary complex is an alternative approach. Methodology: The clinical and radiological examinations of a 29-year-old male revealed maxillary retrognathism and mandibular prognathism without a vertical abnormality. The patient was treated with maxillary advancement by DO and mandibular setback surgery. Results: Long-term functional muscle exercises were scheduled. No relapse has occurred. Conclusions: We believe that the patient’s cooperation and commitment to the functional exercise program played the most important role in the long-term success.  How to cite this article: Apaydin A, Yenigun S, Can T. Distraction Osteogenesis: Treatment of a Case with Maxillary Hypoplasia and Mandibular Prognatism. Int Dent Res 2011;3:92-94. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.