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Aim: This study compared the stress distributions of endodontically treated tooth restored with carbon and titanium post during different loading conditions. Methodology: A 3-dimensional finite element model was created to represent an endodontically treated maxillary central incisor tooth with its supporting structures. Stress distribution and stress values were then calculated by considering the three dimensional von Mises stress criteria. Results: A 100-N static vertical occlusal load was applied on the node at the center of occlusal surface of the tooth. The von Mises stress values for carbon post model was on the coronal third and the cervical area of the root in the range of 353.149 and 13.878 MPa,  for titanium post model was 540.736 and 22.777 MPa. Conclusion: This study shows that the titanium post yields larger stresses than the carbon post.  How to cite this article: Adiguzel O, Kaya S, Yigit Ozer S, Deger Y, Goncu Basaran E, Yavuz I. Three-dimensional Finite Element Analysis of Endodontically Treated Tooth Restored with Carbon and Titanium Posts. Int Dent Res 2011;2:55-59. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.