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An efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot andmulticomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammoniumacetate under solvent-free condition is reported. Highly efficient role of Y(NO3)3×6H2O as catalystin this synthesis was shown. By this advantage, several polysubstituted imidazoles as pharmaceutical importantmolecules can be prepared in high yield and high purity. This method is very easy and rapid forthe synthesis of imidazole derivatives. All products were deduced from their IR and NMR spectroscopicand elemental analysis data. The catalyst exhibited remarkable reusable activity. (doi: 10.5562/cca1979

Facile and Rapid Synthesis of Polysubstituted Imidazoles by Employing Y(NO3)3×6H2O as Catalyst