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A new polyketide, fusaequisin A (1), was isolated from rice cultures of Fusarium equiseti SF-3-17, an endophytic fungus previously discovered during screening of medicinal plants in Cameroon. The structure of 1 was determined using spectroscopic methods. Fusaequisin A (1) exhibited moderate antimicrobial activity against Staphylococcus aureus NBRC 13276 and Pseudomonas aeruginosa ATCC 15442 at a concentration of 200 μg per disk.

A Polyketide Metabolite from an Endophytic Fusarium equiseti in a Medicinal Plant