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Since inflammation is an important contributor to atherosclerosis, gene variants mediating inflammation are of interest. We investigated gene variants in acute phase serum amyloid-A (SAA), a sensitive indicator of inflammatory activity, and their associations with cardiovascular disease (CVD) and HDL cholesterol. Interaction of the SAA genes with genetic variants of their regulators, IL-1, IL-6 and TNF-alpha in influencing CVD was also explored.

journal of atherosclerosis and thrombosis

Association of Genetic Variation in Serum Amyloid-A with Cardiovascular Disease and Interactions withIL6, IL1RN, IL1.BETA. and TNF Genes in the Cardiovascular Health Study