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A point mutation of apolipoprotein A-I, V156E, is naturally occurring and is found in Oita, Japan. V156E of apoA-I (apoA-Ioita) shows unique structural and functional properties and more potent antioxidant activity against copper-mediated low-density lipoprotein (LDL) oxidation in vitro.

journal of atherosclerosis and thrombosis

A Reconstituted High Density Lipoprotein Containing the V156E Mutant of Apolipoprotein A-I Exhibits Anti-Atherosclerotic Activity in Apo-E Deficient Mice