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Phospholipase A 2 receptor 1 (PLA 2 R) has multiple biological functions other than functioning as a receptor for secretory PLA 2 s. Two nonsynonymous polymorphisms in the C-type lectin-like domains (CTLD) 1 of PLA 2 R gene have been associated with idiopathic membranous nephropathy. This study examined whether the same PLA 2 R polymorphisms may alter functions of PLA 2 R in cells expressing the variant PLA 2 R. In addition, the clinical relevance of the experiment was examined.

journal of atherosclerosis and thrombosis

Phospholipase A&lt;sub&gt;2&lt;/sub&gt; Receptor Gene Polymorphisms Alter its Functions and Present a Genetic Risk of an Increased Intima-Media Thickness of the Carotid Artery