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This study was to explore whether activating transcription factor 6 (ATF6), an important sensor to endoplasmic reticulum (ER) stress, would mediate oxidized low-density lipoprotein (ox-LDL)- induced cholesterol accumulation and apoptosis in cultured macrophages and the underlying molecular mechanisms.

Activating Transcription Factor 6 Mediates Oxidized LDL-Induced Cholesterol Accumulation and Apoptosis in Macrophages by Up-Regulating CHOP Expression