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This study compared the effect of doubling the dose of pravastatin with that of adding ezetimibe to low-dose pravastatin on the LDL cholesterol (LDL-C) level and on cholesterol absorption and synthesis markers. The tolerability of the 2 regimens was also compared.

journal of atherosclerosis and thrombosis

Double-Dose Pravastatin Versus Add-On Ezetimibe with Low-Dose Pravastatin -Effects on LDL Cholesterol, Cholesterol Absorption, and Cholesterol Synthesis in Japanese Patients with Hypercholesterolemia (PEAS study)