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More than half a century ago, Carl Jung and Wolfgang Pauli developed a revolutionary hypothesis: natural phenomena are ruled not only by the principle of causality, but also by a kind of natural order that interconnects and regulates all events. Jung designated it as “principle of synchronicity or equivalence” (SE), according to whether or not it was perceived by the human mind.1 Currently, the effect of the principle of SE on the natural world is known as “chronobiology”. The effect of the principle of SE on health and disease processes is known as “chronomedicine”. Modern research methods allow for the identification of organization patterns that, in spite of their importance, usually go unnoticed by the human mind. This paper briefly describes the origin, evolution and significance of the concept of SE in modern medicine.2,3

The principle of synchronicity-equivalence and chronomedicine: relevance and methodological exploration