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An efficient method for the synthesis of thiazolidinones from the microwave-assisted, three-component mixture of an aromatic aldehyde, a 2-amino-4H-benzothiopyrano[4,3-d]thiazole and meraptoacetic acid is described. The transformation of the amino group of 2-amino-4H-[1]benzothiopyrano[4,3-d]thiazo- les into a thiazolidinone ring has not been reported to date. In vitro their anticancer activity was evaluated by MTT method. The results of bioactivities evaluation showed the compound 4 exhibited the best anticancer activity and its IC50 was 5.76 ?M, 6.19 ?M, 6.67 ?M against gastric cancer cells (SGC-7901), cervical cancer cells (Hela) and lung cancer cells (A-549), respectively.</p

Microwave-assisted Synthesis of New 1,3-thiazolidin-4-ones and Evaluation of Their Anticancer Efficacy