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<p>Recording of saccadic eye movements has proved to be a valuable tool for investigation of brain function and dysfunction and is very sensitive to centrally acting drugs. Since there is a lack of agreement concerning velocity–amplitude characteristics of saccadic eye movements, the present study obtained saccadic eye movements from 24 healthy subjects using indigenously developed electro-oculographic recording and analysis system in forward and countdown sequence. The validity of the system was further tested by evaluating the psychotropic effects of 5mg zolpidem and 500mg caffeine in randomized, double blind, placebo controlled three way cross over design on 24 healthy subjects. Saccadic eye movements were measured at baseline and 1, 2 and 3 hrs after administration of study medication. Mean (±SD) values for peak saccadic velocity (PSV) over saccades of ±10, ±20, ±30, ±40, ±50 & ±60 degrees were in agreement with those previously reported. Zolpidem produced statistically significant decrease in PSV compared to placebo at all the angular displacements at 1 & 2 hrs. In contrast, caffeine produced non-significant increase in PSV at all angular displacements at 1hr. Similarly latency period (LP) increased with zolpidem and decreased with caffeine compared to placebo. The electro-oculographic recording and analysis system is simple, sensitive to centrally acting drug effects and therefore has potential for future experimental psychomotor assessment studies.</p

An Electrooculographic Method for the Evaluation of Psychotropic Drugs on Saccadic Eye Movements in Healthy Subjects