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In vitro study the capacity of isolated cytotrophoblast cells (placental cells) treated with cocaine hydrochloride ranging in dose level from 1-3.00 ?molar (0.25-75 mg/ml).to synthesize progesterone was examined. 25 hydroxycholesterol (OHC) or low density lipoprotein (LDL was added in the media as substrate to stimulate progesterone synthesis. In situ study, prostaglandins levels (PGE2 and PGF2?) were measured in the aspirated amniotic fluid obtained from subjects who used cocaine throughout their pregnancy. The data show progesterone synthesis was significantly decreased (p levels in the aspirated amniotic fluid were significantly increased (p cAMP synthesis in the isolated cytotrophoblast cells, cAMP level was measured in the presence of cocaine the data showed decreased cAMP level (p>0.01). Data on birth weights of newborn and gestational age of mothers in cocaine users showed a significant decrease (p complications in pregnancy showed significant increase (p We conclude that cocaine induced decreased progesterone synthesis in the placental cells and an increased prostaglandins level in the amniotic fluid is the cause of early termination of pregnancy in subjects using cocaine during pregnancy.

global journal of health science

In Vitro Study Cocaine Decreased Progesterone Synthesis in the Isolated Cytotrophoblast Cells and in Situ Study PGE2 and PGF2? Levels Increased N the Amniotic Fluid in Cocaine Users in Humans